反应详情

N-Cyclopropyl-6-[4-[(3-chlorophenyl)phenylmethyl]-1-piperazinyl]hexanesulfonamide (13.03 g, 26.59 mmol) prepared in the same manner as in Example 1 was dissolved in ethanol (100 ml). Fumaric acid (4.01 g, 34.55 mmol) was added thereto. After dissolving the mixture with heating, the mixture was cooled in an ice bath to allow the mixture to crystallize. The crystals were filtered, washed with a small amount of ethanol, and dried at 80° C. in vacuo, to give N-cyclopropyl-6-[4-[(3-chlorophenyl)phenylmethyl]-1-piperazinyl]hexanesulfonamide fumarate (15.11 g) as colorless prisms (yield based on N-cyclopropyl-6-[4-[(3-chlorophenyl)phenylmethyl]-1-piperazinyl]hexanesulfonamide: 93.7%).

1. dissolutionAfter dissolving the mixture
2. temperaturewith heating
3. temperaturethe mixture was cooled in an ice bath
4. customto crystallize
5. filtrationThe crystals were filtered
6. washwashed with a small amount of ethanol
7. customdried at 80° C. in vacuo
8. customto give