反应详情

N-Cyclopropyl-6-[4-[(3-chlorophenyl)phenylmethyl]-1-piperazinyl]hexanesulfonamide (1.00 g, 2.04 mmol) prepared in the same manner as in Example 1 was dissolved in methanol (10 ml). A 15% HCl-methanol solution was added thereto to make the solution acidic, and the solvent was then removed by evaporation in vacuo. Acetone was added to the residue, and the precipitated crystals were collected by filtration. The crystals were recrystallized from ethanol, to give N-cyclopropyl-6-[-4-[(3-chlorophenyl)phenylmethyl]-1-piperazinyl]hexanesulfonamide dihydrochloride (0.87 g) as colorless prisms (yield based on N-cyclopropyl-6-[-4-[(3-chlorophenyl)phenylmethyl]-1-piperazinyl]hexanesulfonamide: 75.7%).

1. customthe solvent was then removed by evaporation in vacuo
2. additionAcetone was added to the residue
3. filtrationthe precipitated crystals were collected by filtration
4. customThe crystals were recrystallized from ethanol
5. customto give