Hydrochloric Acid → N-cyclopropyl-6-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]hexanesulfonamide dihydrochloride

Participants

Reaction Steps

N-Cyclopropyl-6-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]hexanesulfonamide (6.20 g, 12.65 mmol) prepared in the same manner as in Example 4 was dissolved in methanol (20 ml). 2 M Hydrochloric acid (factor 1.004) (15.00 ml) was added thereto, and the solvent was then removed by evaporation in vacuo. Acetone was added to the residue, and the precipitated crystals were collected by filtration. The crystals were recrystallized from acetone, to give N-cyclopropyl-6-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]hexanesulfonamide dihydrochloride (5.60 g) as colorless prisms (yield based on N-cyclopropyl-6-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]hexanesulfonamide: 78.6%).

Provenance & Evidence