反应详情

1-[(4-Chlorophenyl)phenylmethyl]piperazine (573.6 mg, 2.00 mmol) and N,N-diethyl-6-chlorohexanesulfonamide (511.6 mg, 2.00 mmol) were refluxed in N-ethyldiisopropylamine (2 ml) for 6 hours. The reaction mixture was concentrated in vacuo, and water was added thereto. The mixture was extracted with chloroform. The chloroform layer was washed with water, and dried over anhydrous magnesium sulfate. Subsequently, the solvent was removed by evaporation in vacuo. The resulting crude product was purified by column chromatography on silica gel with chloroform-methanol (50:1), to give N,N-diethyl-6-[4-[(4-chlorophenyl)phenylmethyl]1-piperazinyl]hexanesulfonamide (951.0 mg) as a pale brown oil (yield: 94.0%).

1. concentrationThe reaction mixture was concentrated in vacuo, and water
2. additionwas added
3. extractionThe mixture was extracted with chloroform
4. washThe chloroform layer was washed with water
5. dry with materialdried over anhydrous magnesium sulfate
6. customSubsequently, the solvent was removed by evaporation in vacuo
7. customThe resulting crude product was purified by column chromatography on silica gel with chloroform-methanol (50:1)