Dimethyl malonate → Potassium methyl malonate

HRID 565789Notes

Reaction equation

HRID 565789 reaction equation
[OH-].[K+:2].[C:3]([O:10]C)(=[O:9])[CH2:4][C:5]([O:7][CH3:8])=[O:6]>CO>[C:5]([O:7][CH3:8])(=[O:6])[CH2:4][C:3]([O-:10])=[O:9].[K+:2]

Participants

4

Reactant 2

HCID 7943Dimethyl malonateHCID 14797Potassium Hydroxide

Product 1

HCID 2724687Potassium methyl malonateYield 76%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

111.6 g of KOH (1.8 mol) are dissolved in 500 g of methanol, and the solution is added to 264.2 g of dimethyl malonate (2 mol) in the course of 2 h at room temperature. The KPG agitator is operated during this at 50 rpm. This mixes the reaction suspension inadequately, broad edge zones remain virtually unmixed. The reaction suspension is then filtered and the filtration residue is washed with methanol and dried in vacuo. 214.2 g of KMM are is obtained, equivalent to a yield of 76% of theory having a DKM content of <0.2% by weight.

Workup

  1. filtrationThe reaction suspension is then filtered
  2. washthe filtration residue is washed with methanol
  3. customdried in vacuo
  4. custom214.2 g of KMM are is obtained, equivalent to a yield of 76% of theory

Sources & evidence

ORD record
ord-de73d5b82c334f57886048c06b2a8736
Source dataset
uspto-grants-2001_01
Patent number
US06172257B2

Reaction notes

Loading…