HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 6-Chloro-8-iodocoumarin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 5-Chloro-2-hydroxy-3-iodobenzaldehyde | HCID 3772545 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 6-Chloro-8-iodocoumarin | HCID 22608626 | — |
Reaction Steps
A mixture of 3-iodo-5-chlorosalicylaldehyde (100 g, 0.354 mole), acetic anhydride (300 mL) and triethylamine (54 mL) was heated at reflux for 18 hours. Upon cooling, the desired coumarin precipitated as a dark brown crystalline material. This was filtered, washed with hexane/ethyl acetate (4:1, 200 mL), and was air dried. Yield: 60 g (55%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06172256B2 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-d8348ab97dfc4ef191f765bcb9fd706d |
| Source note | uspto-grants-2001_01 |