HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 565812Generated: October 29, 2026
Stannous chloride dihydrate → 2-Chloro-4-hydrazinylbenzonitrile hydrochloride
https://huagongshe.com/reaction/565812
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Stannous chloride dihydrate | HCID 61436 | — |
| Reactant | 4-Amino-2-chlorobenzonitrile | HCID 88728 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Chloro-4-hydrazinylbenzonitrile hydrochloride | HCID 22111849 | — |
Reaction Steps
5 g of 4-amino-2-chlorobenzonitrile and 40 ml of concentrated HCl in 30 ml of THF are mixed at −5° C.; 2.26 g of NaNO2 in 30 ml of water are added and the mixture is left stirring for 2 hours, 30 g of SnCl2.2H2O in 30 ml of concentrated HCl are then added and stirring is maintained at −5° C. for 30 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06172239B2 |
|---|
| Source dataset | uspto-grants-2001_01 |
|---|
| ORD ID | ord-43504c0cd60f475fb19f616d5ff63216 |
|---|
| Source note | uspto-grants-2001_01 |
|---|
