HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 565871Generated: October 28, 2026
3-Cyanopyridine → HCID 18472252, compound
https://huagongshe.com/reaction/565871
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Cyanopyridine | HCID 79 | — |
| Reactant | N-[4-(chloromethyl)phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide | HCID 10809385 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 18472252 | HCID 18472252 | 28.4% |
Reaction Steps
In DMF (3ml) was dissolved N-[4-(chloromethyl)-phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide (160mg), and to the mixture was added 3-cyanopyridine (133mg). The mixture was stirred at 70° C. for 24 hours and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate-methanol to give 3-cyano-1-[4-(7-phenyl-3,4-dihydro-naphthalene-2-carboxamido)benzyl]pyridinium chloride (Compound 22) (58mg) as pale orange crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06172061B2 |
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| Source dataset | uspto-grants-2001_01 |
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| ORD ID | ord-a3dd611288604a0e9807e7ea5a7cd787 |
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| Source note | uspto-grants-2001_01 |
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