HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 565872Generated: October 28, 2026
3-Chloropyridine → 3-Chloro-1-[4-(7-phenyl-3,4-dihydronaphthalene-2-carboxamido)benzyl]pyridinium chloride
https://huagongshe.com/reaction/565872
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Chloropyridine | HCID 12287 | — |
| Reactant | N-[4-(chloromethyl)phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide | HCID 10809385 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-Chloro-1-[4-(7-phenyl-3,4-dihydronaphthalene-2-carboxamido)benzyl]pyridinium chloride | HCID 18472432 | — |
Reaction Steps
In DMF (3ml) was dissolved N-[4-(chloromethyl)-phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide (160mg), and to the mixture was added 3-chloropyridine (122 μl). The mixture was stirred at 70° C. for 24 hours and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate-methanol to give 3-chloro-1-[4-(7-phenyl-3,4-dihydro-naphthalene-2-carboxamido)benzyl]pyridinium chloride (Compound 23) (110mg) as pale yellow crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06172061B2 |
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| Source dataset | uspto-grants-2001_01 |
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| ORD ID | ord-d106ae8277194b919432ba955667b55c |
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| Source note | uspto-grants-2001_01 |
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