4-(4-Bromo-3,5-dimethoxyphenyl)-5-methyloxazole → HCID 58432124, compound

HRID 56588Notes

Reaction equation

HRID 56588 reaction equation
[Br:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([C:10]2[N:11]=[CH:12][O:13][C:14]=2[CH3:15])=[CH:4][C:3]=1[O:16][CH3:17].CON(C)[C:21](=[O:37])[CH:22]([O:35][CH3:36])[C:23]1[CH:28]=[CH:27][C:26]([N:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)=[CH:25][CH:24]=1>>[Br:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([C:10]2[N:11]=[C:12]([C:21](=[O:37])[CH:22]([O:35][CH3:36])[C:23]3[CH:24]=[CH:25][C:26]([N:29]4[CH2:30][CH2:31][O:32][CH2:33][CH2:34]4)=[CH:27][CH:28]=3)[O:13][C:14]=2[CH3:15])=[CH:4][C:3]=1[O:16][CH3:17]

Participants

3

Reactant 2

HCID 584319854-(4-Bromo-3,5-dimethoxyphenyl)-5-methyloxazoleHCID 58431993N,2-dimethoxy-N-methyl-2-(4-morpholinophenyl)acetamide

Product 1

HCID 58432124HCID 58432124, compound

Procedure

1-(4-(4-Bromo-3,5-dimethoxyphenyl)-5-methyloxazol-2-yl)-2-methoxy-2-(4-morpholinophenyl)ethanone was prepared from 4-(4-bromo-3,5-dimethoxyphenyl)-5-methyloxazole and N,2-dimethoxy-N-methyl-2-(4-morpholinophenyl)acetamide according to the procedure used in Example 30. Purification by chromatography (40% EtOAc-hexanes) gave the product as a yellow solid (0.048 g, 13% yield). MS: m/z 531.1 [M+H]+.

Workup

  1. customPurification by chromatography (40% EtOAc-hexanes)

Sources & evidence

ORD record
ord-1ab0bdb96f064d47adb8ac843e2077bc
Source dataset
uspto-grants-2016_09
Patent number
US09434707B2

Reaction notes

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