Potassium Carbonate → HCID 18472402, compound

Participants

Reaction Steps

In THF (10ml) was dissolved (E)-N-[4-[hydroxy(2-pyridyl)methyl]phenyl]-3-(4-methylphenyl)cinnamamide (200mg), and to the mixture was added 70% mCPBA (152mg). The mixture was stirred at room temperature for 6 hours, and to the solution were added saturated sodium thiosulfate solution (10ml) and saturated potassium carbonate (10ml). The mixture was stirred at room temperature for 30 minutes and extracted with ethyl acetate. The organic layer was washed with saturated sodium chloride solution, dried with anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate-methanol to give (E)-N-[4-[hydroxy(1-oxido-2-pyridyl)methyl]phenyl]-3-(4-methylphenyl)cinnamamide (Compound 80) (123mg) as colorless crystals.

Provenance & Evidence