HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 1-Methyl-1-(4-(3-(4-fluorophenyl)cinnamoylamino)benzyl)piperidinium iodide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | 1-(4-(3-(4-Fluoro-phenyl)cinnamoylamino)benzyl)piperidine | HCID 53967771 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-Methyl-1-(4-(3-(4-fluorophenyl)cinnamoylamino)benzyl)piperidinium iodide | HCID 86756160 | — |
Reaction Steps
A solution of Compound 83 (0.25g) and methyl iodide (0.2ml) in dimethylformamide (5ml) was stirred at room temperature over night. The solvent was evaporated, and to the residue was added ethyl acetate. Precipitated crude crystal was filtered, which were recrystallized from ethanol to give 1-methyl-1-(4-(3-(4-fluorophenyl)cinnamoylamino)-benzyl)piperidinium iodide (Compound 87) (0.27g) as pale brown crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06172061B2 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-52ed892f85d04802acc85618f9cad1dd |
| Source note | uspto-grants-2001_01 |