N,2-dimethoxy-N-methyl-2-(4-morpholinophenyl)acetamide → 1-(5-(4-Bromo-3,5-dimethoxyphenyl)thiophen-2-yl)-2-methoxy-2-(4-morpholinophenyl)ethanone

Participants

Role	Name	HCID	Charge
Reactant	N,2-dimethoxy-N-methyl-2-(4-morpholinophenyl)acetamide	HCID 58431993	—
Reactant	2-(4-Bromo-3,5-dimethoxyphenyl)thiophene	HCID 58432009	—
Product	1-(5-(4-Bromo-3,5-dimethoxyphenyl)thiophen-2-yl)-2-methoxy-2-(4-morpholinophenyl)ethanone	HCID 58432140	—

Reaction Steps

1-(5-(4-Bromo-3,5-dimethoxyphenyl)thiophen-2-yl)-2-methoxy-2-(4-morpholinophenyl)ethanone was prepared from 2-(4-bromo-3,5-dimethoxyphenyl)thiophene and N,2-dimethoxy-N-methyl-2-(4-morpholinophenyl)acetamide according to the procedure used in Example 30. Purification by chromatography (40% EtOAc-hexanes) gave the product as a yellow solid (0.122 g, 46% yield). MS: m/z 532.4 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09434707B2
Source dataset	uspto-grants-2016_09
ORD ID	ord-2df9f853fd694a9fa7085158839a64e1
Source note	uspto-grants-2016_09