Triethylamine → HCID 18472328, compound

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Reaction Steps

To a solution of 7-(3-pyridyl)-2,3-dihydro-1-benzoxepine-4-carboxylic acid (0.15g), 4-(N-methyl-N-(tetra-hydropyran-4-yl)aminomethyl)aniline (0.12g) and triethylamine (0.16ml) in dimethylformamide (50ml) was added diethyl cyano-phosphate (0.1ml) under ice-cooling, and the mixture was stirred under nitrogen atmosphere at room temperature over night. The solvent was evaporated, and the residue was purified with silica gel column (methanol/ethyl acetate/triethylamine) to give crude crystals, which were recrystallized from ethanol-hexane to give 7-(3-pyridyl)-N-(4-((N-tetrahydropyran-4-yl-N-methylamino)-methyl)-phenyl)-2,3-dihydro-1-benzoxepine 4-carboxamide (Compound 146) (0.06g) as colorless crystals.

Provenance & Evidence