反应详情

324 mg (purity 85%, 2.5 mmol, 3 eq.) of 2,2,2-trifluoroethaneimidamide were added to a suspension of 200 mg (0.82 mmol) of 2-bromo-1-(4-nitrophenyl)ethanone and 500 mg of sodium sulphate in 10 ml of acetonitrile, and the mixture was treated in an ultrasonic bath for 1 h and then stirred at RT. The sodium sulphate was then filtered off and the filtrate was concentrated under reduced pressure. The residue was purified by preparative HPLC (Reprosil C18, water/methanol gradient). Yield: 104 mg (49% of theory)

1. additionthe mixture was treated in an ultrasonic bath for 1 h
2. filtrationThe sodium sulphate was then filtered off
3. concentrationthe filtrate was concentrated under reduced pressure
4. customThe residue was purified by preparative HPLC (Reprosil C18, water/methanol gradient)