反应详情

A solution of 3.6 g (11.5 mmol) of tert-butyl 2-(2-fluoro-4-nitrobenzoyl)-2-methylhydrazinecarboxylate in 57 ml of 4-molar hydrochloric acid/dioxane solution was stirred at RT for 3 h. The reaction mixture was concentrated under reduced pressure and the residue was taken up in ethyl acetate and washed with saturated aqueous sodium bicarbonate solution. The organic phase was dried (sodium sulphate), filtered and concentrated under reduced pressure. Yield: 2.0 g (81% of theory)

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. washwashed with saturated aqueous sodium bicarbonate solution
3. dry with materialThe organic phase was dried (sodium sulphate)
4. filtrationfiltered
5. concentrationconcentrated under reduced pressure