5-(4-nitrophenyl)-3H-1,3-oxazol-2-one → 5-(4-Aminophenyl)-1,3-oxazol-2(3H)-one

HRID 56615노트

반응식

HRID 56615 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:14][C:13](=[O:15])[NH:12][CH:11]=2)=[CH:6][CH:5]=1)([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[O:14][C:13](=[O:15])[NH:12][CH:11]=2)=[CH:8][CH:9]=1

참가 물질

4

반응물 1

HCID 8221335-(4-nitrophenyl)-3H-1,3-oxazol-2-one

생성물 1

HCID 1176227935-(4-Aminophenyl)-1,3-oxazol-2(3H)-one

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A solution of 1.1 g (5.4 mmol) of 5-(4-nitrophenyl)-1,3-oxazol-2(3H)-one in 40 ml of ethanol was hydrogenated in the presence of 111 mg of palladium (10% on activated carbon) at RT and standard pressure for 5 d. The reaction mixture was then filtered through Celite and the residue was washed with ethanol. The combined filtrates were concentrated under reduced pressure. The residue was used for the next step without further purification. Yield: 626 mg (purity 88%, 58% of theory)

후처리

  1. filtrationThe reaction mixture was then filtered through Celite
  2. washthe residue was washed with ethanol
  3. concentrationThe combined filtrates were concentrated under reduced pressure
  4. customThe residue was used for the next step without further purification

출처 및 근거

ORD 기록
ord-30bea0a6042a4218bea4e67ef947e621
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434690B2

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