反应详情

Mixture of (1-hydroxy-4-pentylcyclohexyl)-3,5-difluorobenzene (300 mmol), the Amberlist 15E (4.0 g), and 1,000 ml of toluene was refluxed for 6 hours. After allowed to cool, the Amberlist 15E was filtered off, the solvent was distilled off, and the residue was purified by column chromatography (eluent: heptane) to give a (4-pentyl-1-cyclohexenyl)-3,5-difluorobenzene (170 mmol).

1. temperatureto cool
2. filtrationthe Amberlist 15E was filtered off
3. distillationthe solvent was distilled off
4. customthe residue was purified by column chromatography (eluent: heptane)