Hydrochloric Acid → HCID 178477061, compound

Participants

Reaction Conditions

Reaction Steps

3-(2-Acetylthioethyl)-1-triphenylmethyl-1,2,4-triazole (0.50) was dissolved in THF (2.5 ml). To the solution were added 10% hydrochloric acid (0.5 ml) and methanol (10 ml). The mixture was stirred for 1.5 hour at 25° C. The reaction mixture was concentrated, to which was added NaHCO3, to make the solution to be weakly basic, followed by extraction three times with THF-ethyl acetate (1:1, 10 ml). Organic layers were combined and dried over anhydrous magnesium sulfate, followed by concentration. The concentrate was purified by means of a column chromatography (carrier: silica gel, 20 g, developing solvent: acetone) to afford the title compound (134 mg) as a crystalline product, m.p.84-86° C.

Provenance & Evidence