Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-Butyl 2-bromopropanoate → tert-Butyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)propanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-Butyl 2-bromopropanoate | HCID 545327 | — |
| 반응물 | 4-Bromo-2-hydroxypyridine | HCID 817115 | — |
| 생성물 | tert-Butyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)propanoate | HCID 117622807 | — |
반응 단계
6.0 g (34.5 mmol) of 4-bromopyridin-2(1H)-one and 7.9 g (37.9 mmol) of tert-butyl 2-bromopropanoate (racemate) were reacted according to General Method 4B. After removal of the DMF, the desired product was precipitated with water and then purified further by flash chromatography (silica gel 60, mobile phase: cyclohexane/ethyl acetate mixtures). Yield: 7.4 g (69% of theory)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09434690B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-a3d9a6c70f324a2bbe12ad35708693af |
| 출처 메모 | uspto-grants-2016_09 |