Ammonia → HCID 21266002, compound

Participants

Reaction Steps

Gaseous ammonia was conducted into a solution of 14.4 g of dimorpholin-4-yl-phosphinic acid (5-phenyl-3H-thieno[3,2-e][1,4]-diazepin-2-yl) ester at room temperature while stirring until the starting product had reacted completely. After removal of the solvent in a vacuum the residue was extracted with dichloromethane/water in the presence of a small amount of methanol. The aqueous phase was washed several times with dichloromethane, the dichloromethane extracts were dried with sodium sulphate, filtered and evaporated in a vacuum. The residue was suspended in dichloromethane and stirred for 0.5 h. There were obtained 2.9 g of crude 5-phenyl-3H-thieno[3,2-e][1,4]diazepin-2-ylamine which was used without further purification as the starting product for the step described below.

Provenance & Evidence