Ammonia → HCID 21266001, compound

Participants

Reaction Steps

60 ml of 25% aqueous ammonia solution and 30 ml of methanol were added to a suspension of 3.0 g of 7-iodo-5-(2-pyridyl)-3H-1,4-benzodiazepine-2(1H)-thione in 200 ml of tetrahydrofuran. The mixture was stirred at room temperature for 16 h., with the solution which formed being concentrated to about 50 ml in a vacuum. The crystals were filtered off, washed with water, dried, stirred in 25 ml of dioxan at 100° C., cooled and filtered off. There were obtained 2.35 g of 2-amino-7-iodo-5-(2-pyridyl)-3H-1,4-benzodiazepine of m.p. 228-229° C.

Provenance & Evidence