Hydrogen Peroxide → HCID 21266062, compound

Participants

Reaction Steps

3.7 g (12.37 mmol) of 5-amino-1-[1-(1-hydroxy-ethyl)-4-phenyl-butyl]-3methyl-1H-pyrazole-4-carbonitrile and 950 mg of tetrabutylammonium hydrogen sulphate are dissolved in 25 ml of CH2Cl2, 5.5 ml of 5M NaOH and 7 ml of 30% strength H2O2 are added, and the mixture is stirred for 15 hours at room temperature. The phases are separated, the organic phase is extracted twice with water, the organic phase is dried over Na2SO4, and the solvent is removed in vacuo. Yield: 3.24 g (83%), Rf=0.11 (petroleum ether/ethyl acetate=1:1)

Provenance & Evidence