4-Fluorophenylacetyl chloride → 6-(4-Fluoro-benzyl)-1-[1-(1-hydroxy-ethyl)-4-phenyl-butyl]-1,5-dihydro-pyrazolo-[3,4-d]pyrimidin-4-one

Participants

Reaction Steps

Starting from 400 mg (1.32 mmol) of 5-amino-1-[1-(1-hydroxy-ethyl)-4-phenyl-butyl]-1H-pyrazole-4-carboxamide and 570 mg (3.31 mmol) of 4-fluorophenylacetyl chloride, the title compounds are prepared analogously to the protocol of Example 13. This gives 143 mg (27%) of the diastereomer which elutes more rapidly, M.p. 103° C., and 111 mg (21%) of the diastereomer which elutes more slowly, M.p.: 107° C.

Provenance & Evidence