4-Chlorophenylacetyl chloride → 6-(4-Chloro-benzyl)-1-[1-(1-hydroxy-ethyl)-4-phenyl-butyl]-1,5-dihydro-pyrazolo-[3,4-d]pyrimidin-4-one

Participants

Reaction Steps

Starting from 400 mg (1.32 mmol) of 5-amino-1-[1-(1-hydroxy-ethyl)-4-phenyl-butyl]-1H-pyrazole-4-carboxamide and 626 mg (3.77 mmol) of 4-chlorophenylacetyl chloride, the title compounds are prepared analogously to the protocol of Example 13. This gives 150 mg (26%) of the diastereomer which elutes more rapidly, M.p.: 125° C., and 90 mg (16%) of the diastereomer which elutes more slowly, M.p.: 101° C.

Provenance & Evidence