3-Methoxyphenylacetyl chloride → 1-[1-(1-Hydroxy-ethyl)-4-phenyl-butyl]-6-(3-methoxy-benzyl)-1,5-dihydro-pyrazolo-[3,4-d]pyrimidin-4-one

Participants

Reaction Steps

Starting from 400 mg (1.32 mmol) of 5-amino-1-[1-(1-hydroxy-ethyl)-4-phenyl-butyl]-1H-pyrazole-4-carboxamide and 610 mg (3.81 mmol) of 3-methoxyphenylacetyl chloride, the title compounds are prepared analogously to the protocol of Example 13. This gives 160 mg (28%) of the diastereomer which elutes more rapidly, M.p.: 92° C., and 145 mg (25%) of the diastereomer which elutes more slowly, M.p.: 54° C.

Provenance & Evidence