4-Methoxyphenylacetyl chloride → 1-[1-(1-Hydroxy-ethyl)-4-phenyl-butyl]-6-(4-methoxy-benzyl)-1,5-dihydro-pyrazolo-[3,4-d]pyrimidin-4-one

Participants

Reaction Steps

Starting from 1 g (3.31 mmol) of 5-amino-1-[1-(1-hydroxy-ethyl)-4-phenyl-butyl]-1H-pyrazole-4-carboxamide and 1.52 g (8.26 mmol) of 4-methoxyphenylacetyl chloride, the title compounds are prepared analogously to the protocol of Example 13. This gives 240 mg (17%) of the diastereomer which elutes more rapidly, M.p.: 41° C., and 134 mg (9%) of the diastereomer which elutes more slowly, M.p.: 48° C.

Provenance & Evidence