Benzeneacetyl chloride, 4-bromo- → 6-(4-Bromo-benzyl)-1-[1-(1-hydroxy-ethyl)-4-phenyl-butyl]-1,5-dihydro-pyrazolo-[3,4-d]pyrimidin-4-one

Participants

Reaction Steps

Starting from 2.1 g (6.95 mmol) of 5-amino-1-[1-(1-hydroxy-ethyl)-4-phenyl-butyl]-1H-pyrazole-4-carboxamide and 4.05 mg (17.38 mmol) of 4-bromophenylacetyl chloride, the title compounds are prepared analogously to the protocol of Example 13. This gives 594 mg (18%) of the diastereomer which elutes more rapidly, M.p.: 117° C., and 372 mg (11%) of the diastereomer which elutes more slowly, M.p.: 116° C.

Provenance & Evidence