2-(3,4-Dichlorophenyl)acetyl chloride → HCID 131722270, compound

Participants

Reaction Steps

Starting from 805 mg (2.55 mmol) of 5-amino-1-[1-(1-hydroxy-ethyl)-4-phenyl-butyl]-3-methyl-1H-pyrazole-4-carboxamide and 1.41 g (6.59 mmol) of 3,4-dichlorophenylacetyl chloride, are employed analogously to the protocol of Example 32 and 33. This gives 217 mg (18%) of the diastereomer which elutes more rapidly, Rf=0.2 (cyclohexane/ethyl acetate=2:1) and 186 mg (15%) of the diastereomer which elutes more slowly, M.p.: 160° C.

Provenance & Evidence