HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 135702882, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Methyl 2-(1,3-dioxaindan-5-yl)acetate | HCID 266588 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 21266063 | HCID 21266063 | — |
| Solvent | Potassium tert-butoxide | HCID 23665647 | — |
| Product | HCID 135702882 | HCID 135702882 | 50% |
Reaction Steps
19 mg (0.063 mmol) of 5-amino-1-(1-methyl-4-phenyl-butyl)-3-ethyl-1H-pyrazole-4-carboxamide and 35 mg (0.180 mmol) of methyl 3,4-methylenedioxyphenylacetate are refluxed for 6 hours in 0.9 ml of 0.5M ethanolic potassium tert-butoxide solution. After dichloromethane and saturated aqueous sodium hydrogen carbonate solution have been added, the phases are separated. Purification by chromatography gives 14 mg (48%) of a solid, Rf=0.64 (dichloromethane/methanol=15:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06174884B1 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-8b035a99bd384da4b51f3482b1539408 |
| Source note | uspto-grants-2001_01 |