Methyl 2-(1,3-dioxaindan-5-yl)acetate → HCID 135702880, compound

Participants

Reaction Steps

10 mg (0.037 mmol) of 5-amino-1-[1-(1-hydroxy-ethyl)-4-phenyl-butyl]-3-methyl-1H-pyrazole-4-carboxamide and 30 mg (0.129 mmol) of methyl 3,4-methylenedioxyphenylacetate are refluxed for 6 hours in 0.3 ml of a 0.5M ethanolic potassium tert-butoxide solution. After dichloromethane and saturated aqueous sodium hydrogen carbonate solution have been added, the phases are separated. Purification by chromatography gives 5 mg (31%) of a solid, Rf=0.44 (dichloromethane/methanol=15:1).

Provenance & Evidence