Methyl 2-(1,3-dioxaindan-5-yl)acetate → 6-(3,4-Methylenedioxy-benzyl)-1-(3-nonyl)-3-methyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

Participants

Reaction Steps

15 mg (0.055 mmol) of 5-amino-3-methyl-1-(3-nonyl)-1H-pyrazole-4-carboxamide and 53 mg (0.274 mmol) of methyl 3,4-methylenedioxyphenylacetate are refluxed for 6 hours in 0.5 ml of a 0.5M ethanolic sodium ethoxide solution. After dichloromethane and saturated aqueous sodium hydrogen carbonate solution have been added, the phases are separated. Purification by chromatography gives 11.8 mg (52%) of a solid, Rf=0.65 (dichloromethane/methanol=15:1).

Provenance & Evidence