HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → HCID 136132157, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Methyl 2-(3,4-dichlorophenyl)acetate | HCID 1268257 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | HCID 59932330 | HCID 59932330 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 136132157 | HCID 136132157 | 55.1% |
Reaction Steps
10 mg (0.019 mmol) of 5-amino-3-propyl-1-(4-decyl)-1H-pyrazole-4-carboxamide and 20 mg (0.091 mmol) of methyl 3,4-dichlorophenylacetate are refluxed for 6 hours in 0.3 ml of a 0.5M ethanolic sodium ethoxide solution. After dichloromethane and saturated aqueous sodium hydrogen carbonate solution have been added, the phases are separated. Purification by chromatography gives 5 mg (48%) of a solid, Rf=0.70 (dichloromethane/methanol=15:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06174884B1 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-e81c37462eea4f9ca7070e2dd88b9181 |
| Source note | uspto-grants-2001_01 |