Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 1-Benzyl-3-methyl-5-nitroindazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Benzylhydrazine dihydrochloride | HCID 146540 | — |
| 반응물 | 1-(2-Fluoro-5-nitrophenyl)ethan-1-one | HCID 2781067 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 1-Benzyl-3-methyl-5-nitroindazole | HCID 21952162 | — |
반응 단계
2-Fluoro-5nitroacetophenone (H. Sato et al, Bioorganic and Medicinal Chemistry Letters, 5(3), 233-236, 1995) (0.24 g) was treated with triethylamine (0.73 ml) and benzyl hydrazine dihydrochloride (0.255 g) in ethanol (20 ml) at reflux under N2 for 8 days. The mixture was cooled and the solid 1-benzyl-3-methyl-5-nitroindazole (0.16 g) was collected by filtration; m/z (M+1)+268.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06174889B1 |
| 출처 데이터셋 | uspto-grants-2001_01 |
| ORD ID | ord-d2b18acabc104072aab816246d4928f7 |
| 출처 메모 | uspto-grants-2001_01 |