Acetic Anhydride → HCID 135817447, compound

HRID 566388Notes

Reaction equation

HRID 566388 reaction equation
N1[C:5]([C:6]2[N:16]=[CH:15][C:9]3[N:10]=[CH:11][NH:12][C:13](=[O:14])[C:8]=3[CH:7]=2)=[N:4][N:3]=N1.[C:17](OC(=O)C)(=[O:19])[CH3:18]>>[CH3:18][C:17]1[O:19][C:5]([C:6]2[N:16]=[CH:15][C:9]3[N:10]=[CH:11][NH:12][C:13](=[O:14])[C:8]=3[CH:7]=2)=[N:4][N:3]=1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 178518713HCID 178518713, compound

Product 1

HCID 135817447HCID 135817447, compound

Procedure

6-(1,2,3,4-Tetrazol-5-yl)-pyrido[3,4-d]pyrimidin-4-one (1.4 g) in acetic anhydride (10 ml) was heated at reflux under N2 for 2.5 hours. The cooled mixture was absorbed onto silica and purified by chromatography to give the title compound 90.14 g) as a beige solid; δH [2H6]DMSO 13.0(1H,bs), 9.30 (1H,s), 8.66 (1H,s), 8.47 (1H,s) 2.75 (3H,s); m/z (M+1+)230.

Workup

  1. temperatureat reflux under N2 for 2.5 hours
  2. customThe cooled mixture was absorbed onto silica
  3. custompurified by chromatography

Sources & evidence

ORD record
ord-559d1d2348d94bf3a8cbb08d9107386b
Source dataset
uspto-grants-2001_01
Patent number
US06174889B1

Reaction notes

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