1-(3-Pyridylmethyl)-1H-indazol-5-ylamine → N6,N6-Dimethyl-N4-(1-pyridin-3-ylmethyl-1H-indazol-5-yl)-pyrido[3,4]-pyrimidine-4,6-diamine hydrochloride

HRID 566397Notes

Reaction equation

HRID 566397 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][N:8]2[C:16]3[C:11](=[CH:12][C:13]([NH2:17])=[CH:14][CH:15]=3)[CH:10]=[N:9]2)[CH:2]=1.[Cl:18][C:19]1[C:20]2[CH:28]=C(N(C)C)N=[CH:25][C:21]=2[N:22]=[CH:23][N:24]=1>>[ClH:18].[CH3:7][N:8]([CH3:16])[N:9]1[CH:10]=[CH:25][C:21]2[N:22]=[CH:23][N:24]=[C:19]([NH:17][C:13]3[CH:12]=[C:11]4[C:16](=[CH:15][CH:14]=3)[N:8]([CH2:7][C:3]3[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=3)[N:9]=[CH:10]4)[C:20]=2[CH2:28]1

Participants

3

Reactant 2

HCID 219519981-(3-Pyridylmethyl)-1H-indazol-5-ylamineHCID 227274534-Chloro-6-(N,N-dimethylamino)-pyrido[3,4-d]pyrimidine

Product 1

HCID 70247206N6,N6-Dimethyl-N4-(1-pyridin-3-ylmethyl-1H-indazol-5-yl)-pyrido[3,4]-pyrimidine-4,6-diamine hydrochloride

Procedure

Prepared according to Procedure A from 1-(3-Pyridylmethyl)-1H-indazol-5-ylamine and 4-chlor-6-(N,N-dimethylamino)-pyrido[3,4-d]pyrimidine; δH [2H6]DMSO 11.50 (1H,s), 9.90(1H,s), 8.65(1H,d), 8.60(2H,m), 8.25(1H,s), 8.14(1H,s), 7.91(1H,d), 7.75 (2H,m), 7.70(1H,s), 7.50(1H,m), 5.80(2H,s), 3.20(6H,s); m/z (M+1+) 397.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-a611c361630640c3806daf20b806f422
Source dataset
uspto-grants-2001_01
Patent number
US06174889B1

Reaction notes

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