4-Chloro-6-(N,N-dimethylamino)-pyrido[3,4-d]pyrimidine → N4-(1-Benzyl-3-methyl-1H-indazol-5-yl)-N6,N6-dimethyl-pyrido[3,4-d]pyrimidine-4,6-diamine

HRID 566398Notes

Reaction equation

HRID 566398 reaction equation
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([NH2:17])=[CH:14][CH:15]=2)[C:10]([CH3:18])=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[C:20]1[C:21]2[CH:29]=[C:28]([N:30]([CH3:32])[CH3:31])[N:27]=[CH:26][C:22]=2[N:23]=[CH:24][N:25]=1>>[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([NH:17][C:20]3[C:21]4[CH:29]=[C:28]([N:30]([CH3:32])[CH3:31])[N:27]=[CH:26][C:22]=4[N:23]=[CH:24][N:25]=3)=[CH:14][CH:15]=2)[C:10]([CH3:18])=[N:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 227274534-Chloro-6-(N,N-dimethylamino)-pyrido[3,4-d]pyrimidineHCID 541033091-Benzyl-3-methyl-1H-indazol-5-ylamine

Product 1

HCID 22727425N4-(1-Benzyl-3-methyl-1H-indazol-5-yl)-N6,N6-dimethyl-pyrido[3,4-d]pyrimidine-4,6-diamine

Procedure

Prepared according to Procedure A from 1-Benzyl-3-methyl-1H-indazol-5-ylamine and 4-chloro-6-(N,N-dimethylamino)-pyrido[3,4-d]pyrimidine; δH [2H6]DMSO 11.75 (1H,s), 8.90(1H,s), 8.62(1H,s), 8.02(1H,s), 7.70(3H,m), 7.30(5H,m), 5.62(2H,s), 3.30(6H,s) 2.50(3H,s); m/z (M+1+) 410.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-34d87e567129479ab78ea4fec1954bcd
Source dataset
uspto-grants-2001_01
Patent number
US06174889B1

Reaction notes

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