5-Amino-1-(2-fluorobenzyl)-1H-indazole → N4-(1-(2-Fluoro-benzyl)-1H-indazol-5-yl)-N6,N6-dimethyl-pyrido[3,4-d]pyrimidine-4,6-diamine hydrochloride

HRID 566399Notes

Reaction equation

HRID 566399 reaction equation
[F:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([NH2:14])=[CH:11][CH:12]=2)[CH:7]=[N:6]1.[Cl:19][C:20]1[C:21]2[CH:29]=[C:28]([N:30]([CH3:32])[CH3:31])[N:27]=[CH:26][C:22]=2[N:23]=[CH:24][N:25]=1>>[ClH:19].[F:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([NH:14][C:20]3[C:21]4[CH:29]=[C:28]([N:30]([CH3:32])[CH3:31])[N:27]=[CH:26][C:22]=4[N:23]=[CH:24][N:25]=3)=[CH:11][CH:12]=2)[CH:7]=[N:6]1

Participants

3

Reactant 2

HCID 219520555-Amino-1-(2-fluorobenzyl)-1H-indazoleHCID 227274534-Chloro-6-(N,N-dimethylamino)-pyrido[3,4-d]pyrimidine

Product 1

HCID 22727463N4-(1-(2-Fluoro-benzyl)-1H-indazol-5-yl)-N6,N6-dimethyl-pyrido[3,4-d]pyrimidine-4,6-diamine hydrochloride

Procedure

Prepared according to Procedure A from 1-(2-Fluoro-benzyl)-1H-indazol-5-ylamine and 4-chloro-6-(N,N-dimethylamino)-pyrido[3,4-d]pyrimidine; δH [2H6]DMSO 11.45 (1H,s), 8.90(1H,s), 8.63(1H,s), 8.24(1H,s), 8.13(1H,s), 7.87(1H,d), 7.70(1H,d), 7.62(1H,s) 7.36(1H,m), 7.20 (3H,m), 5.75 (2H,s), 3.22(6H,s); m/z (M+) 413.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-fe9cc583eae343a8a84dfce23f811b2e
Source dataset
uspto-grants-2001_01
Patent number
US06174889B1

Reaction notes

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