1-(3-Fluorobenzyl)-1H-indazol-5-amine → (1-(3-Fluoro-benzyl)-1H-indazol-5-yl)-(6-(5-methyl-1,3,4-oxadiazol-2-yl)-pyrido[3,4-d]pyrimidin-4-yl)-amine hydrochloride

HRID 566403Notes

Reaction equation

HRID 566403 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][CH:18]=1)[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([NH2:15])=[CH:12][CH:13]=2)[CH:8]=[N:7]1.[Cl:19][C:20]1[C:21]2[CH:29]=[C:28]([C:30]3[O:31][C:32]([CH3:35])=[N:33][N:34]=3)[N:27]=[CH:26][C:22]=2[N:23]=[CH:24][N:25]=1>>[ClH:19].[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][CH:18]=1)[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([NH:15][C:20]3[C:21]4[CH:29]=[C:28]([C:30]5[O:31][C:32]([CH3:35])=[N:33][N:34]=5)[N:27]=[CH:26][C:22]=4[N:23]=[CH:24][N:25]=3)=[CH:12][CH:13]=2)[CH:8]=[N:7]1

Participants

3

Reactant 2

HCID 71470731-(3-Fluorobenzyl)-1H-indazol-5-amineHCID 22011950HCID 22011950, compound

Product 1

HCID 22727456(1-(3-Fluoro-benzyl)-1H-indazol-5-yl)-(6-(5-methyl-1,3,4-oxadiazol-2-yl)-pyrido[3,4-d]pyrimidin-4-yl)-amine hydrochloride

Procedure

Prepared according to Procedure A from 1-(3-Fluoro-benzyl)-1H-indazol-5-ylamine and 4-chloro-6-(5-methyl-1,3,4-oxadiazol-2-yl)-pyrido[3,4-d]pyrimidine; δH [2H6]DMSO 11.50(1H,s), 9.53(1H,s), 9.41(1H,s), 8.94(1H,s), 8.30(2H,s), 7.90(1H,d), 7.80(1H,dd), 7.45(1H,d),7.25(3H,m) 5.80(2H,s), 2.75 (3H,s); m/z (M+1+) 453.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-a1211e6eb65f4d568c264756af610767
Source dataset
uspto-grants-2001_01
Patent number
US06174889B1

Reaction notes

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