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HRID 566404作成日：2026年10月25日

1-Methylpiperazine → (1-Benzyl-1H-indazol-5-yl)-(6-(4-methyl-piperazin-1-yl)-pyrido[3,4-d]pyrimidin-4-yl)-amine

https://huagongshe.com/reaction/566404

反応式

関与物質

役割名称HCID仕込み量
反応物1-MethylpiperazineHCID 53167—
反応物(1-Benzyl-1H-indazol-5-yl)-(6-chloropyrido[3,4-d]pyrimidin-4-yl)-amineHCID 21952012—
生成物(1-Benzyl-1H-indazol-5-yl)-(6-(4-methyl-piperazin-1-yl)-pyrido[3,4-d]pyrimidin-4-yl)-amineHCID 22727435—

反応手順

4-Methylpiperazine was reacted with (1-Benzyl-1H-indazol-5-yl)-(6-chloro-pyrido[3,4-d]pyrimidin-4-yl)-amine as in Example 24 to give the title compound (Procedure C); δH [2H6]DMSO 9.80(1H,s), 8.82(1H,s), 8.47(1H,s), 8.23(1H,s), 8.15(1H,s), 7.75(1H,d), 7.67(1H,d), 7.54(1H,s), 7.28(5H,m), 5.68(2H,s) 3.64(4H,m), 3.34(4H,m), 2.27(3H,s); m/z (M+) 451.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06174889B1
出典データセットuspto-grants-2001_01
ORD IDord-9060ee56089f42f8844f4fb987b17ce9
出典メモuspto-grants-2001_01