1-(Phenylmethyl)-1H-indazol-5-amine → (1-Benzyl-1H-indazol-5-yl)-(6-benzyloxy-pyrido[3,4-d]pyrimidin-4-yl)-amine hydrochloride

関与物質

反応手順

6-Benzyloxy-4-chloro-pyrido[3,4-d]pyrimidine (0.54 g, ca. 2 mmol) and 5-amino-1-benzyl-1H-indazole (0.458 g, 2.05 mmol) were reacted according to Procedure A to give the title compound as a yellow solid (0.740 g, 1.50 mmol, 75%); δH [2H6]DMSO 11.50(1H,s), 9.00(1H,s), 8.77(1H,s), 8.16-8.33 (3H,m), 7.83(1H,d), 7.71 (1H,dd), 7.13-7.58 (10H,m), 5.69(2H,s), 5.55(2H,s); m/z (M+1+) 459.

情報源と証拠