HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-5-chlorophenylboronic acid → tert-Butyl 2-[4-(2-bromo-5-chlorophenyl)-2-oxopyridin-1(2H)-yl]propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-5-chlorophenylboronic acid | HCID 44558136 | — |
| Reactant | tert-Butyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)propanoate | HCID 117622807 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | tert-Butyl 2-[4-(2-bromo-5-chlorophenyl)-2-oxopyridin-1(2H)-yl]propanoate | HCID 117622670 | — |
Reaction Steps
856 mg (2.75 mmol) of tert-butyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)propanoate (racemate) and 776 mg (3.3 mmol) of 2-bromo-5-chlorophenylboronic acid in the presence of tetrakis(triphenylphosphine)palladium(0) were reacted according to General Method 2A. Yield: 921 mg (80% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434690B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-5e89b4348f11414db29dadbb5b82bbe9 |
| Source note | uspto-grants-2016_09 |