HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Chloromethyl)-1-trityl-1H-imidazole → HCID 15491432, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Chloromethyl)-1-trityl-1H-imidazole | HCID 2763176 | — |
| Reactant | Potassium bis(trimethylsilyl)amide | HCID 3251421 | — |
| Reactant | Methyl [(phenylmethylidene)amino]acetate | HCID 4169153 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 15491432 | HCID 15491432 | — |
Reaction Steps
A solution of potassium bis(trimethylsilyl)amide (11.34 g, 54 mmol) in THF (100 ml) was added dropwise to a mixture of (benzylidene-amino)-acetic acid methyl ester (3.83 g, 21.63 mmol) and 4-chloromethyl-1-trityl-1H-imidazole (21.6 g, 60.18 mmol) in THF (200 ml) at −78° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06174903B1 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-ab5fe1fd22c94b839072267bc0325ec6 |
| Source note | uspto-grants-2001_01 |