Butyl bromide → 3-(n-butylamino)phenol

Participants

Reaction Steps

0.11 mol of n-butyl bromide and 0.1 mol of NaHCO3 are added to 0.1 mol of m-aminophenol in 150 ml of methanol and the mixture is refluxed for 5 h. After cooling, the mixture is filtered and the solvent is removed in vacuo. The oil which remains is fractionated in vacuo, to give 3-(n-butyl-amino)phenol in a yield of 57%; b.p. 110° C. (6·10−5 torr), m.p. 35° C.

Provenance & Evidence