5-Chloro-2-(trifluoromethyl)phenylboronic acid → tert-Butyl 2-{4-[5-chloro-2-(trifluoromethyl)phenyl]-2-oxopyridin-1(2H)-yl}propanoate

Participants

Role	Name	HCID	Charge
Reactant	5-Chloro-2-(trifluoromethyl)phenylboronic acid	HCID 46736817	—
Reactant	tert-Butyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)propanoate	HCID 117622807	—
Catalyst	HCID 178418397	HCID 178418397	—
Product	tert-Butyl 2-{4-[5-chloro-2-(trifluoromethyl)phenyl]-2-oxopyridin-1(2H)-yl}propanoate	HCID 117622679	—

Reaction Steps

2.0 g (6.4 mmol) of tert-butyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)propanoate (racemate) and 1.7 g (7.7 mmol) of 5-chloro-2-(trifluoromethyl)phenylboronic acid in the presence of tetrakis(triphenylphosphine)palladium(0) were reacted according to General Method 2A. Yield: 2.3 g (purity 91%, 82% of theory)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09434690B2
Source dataset	uspto-grants-2016_09
ORD ID	ord-f8233a728e694bc0b079076c904915a3
Source note	uspto-grants-2016_09