HRID566497

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)C(Cc1ccc(C(F)(F)P(=O)(OC(C)(C)C)OC(C)(C)C)cc1)(Cc1ccc(C(F)(F)P(=O)(OC(C)(C)C)OC(C)(C)C)cc1)C(=O)O

HCID21265729

未命名化合物

PRODUCTS

生成物

结构：COC(=O)C(Cc1ccc(C(F)(F)P(=O)(O)O)cc1)(Cc1ccc(C(F)(F)P(=O)(O)O)cc1)C(=O)O

HCID21265722

未命名化合物

收率 35%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID22392675

未命名化合物

PROCEDURE

实验过程

A solution of 2,2-di{4-[(di-tert-butoxyphosphoryl) (difluoro)methyl]benzyl}-3-methoxy-3-oxopropanoic acid(80 mg) in 5 mL of 10:1 TFA/water was stirred for 1 h and then concentrated. The residue was dissolved in 4 mL of water and washed with 2×5 mL of ether and the aqueous solution was lyopholized to give 20 mg of the title compound as a white solid.

WORKUP

后处理

concentrationconcentrated
dissolutionThe residue was dissolved in 4 mL of water
washwashed with 2×5 mL of ether

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3e2b90b898cf4c7ead6d148224f64fda
来源数据集: uspto-grants-2001_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06174874B1
来源说明: uspto-grants-2001_01

反应 SMILES

C([O:5][P:6]([C:13]([F:52])([F:51])[C:14]1[CH:50]=[CH:49][C:17]([CH2:18][C:19]([CH2:27][C:28]2[CH:33]=[CH:32][C:31]([C:34]([P:37]([O:44]C(C)(C)C)([O:39]C(C)(C)C)=[O:38])([F:36])[F:35])=[CH:30][CH:29]=2)([C:23]([O:25][CH3:26])=[O:24])[C:20]([OH:22])=[O:21])=[CH:16][CH:15]=1)([O:8]C(C)(C)C)=[O:7])(C)(C)C>C(O)(C(F)(F)F)=O.O>[F:52][C:13]([F:51])([P:6]([OH:8])([OH:7])=[O:5])[C:14]1[CH:50]=[CH:49][C:17]([CH2:18][C:19]([CH2:27][C:28]2[CH:29]=[CH:30][C:31]([C:34]([F:35])([F:36])[P:37]([OH:44])([OH:39])=[O:38])=[CH:32][CH:33]=2)([C:23]([O:25][CH3:26])=[O:24])[C:20]([OH:22])=[O:21])=[CH:16][CH:15]=1