2,2-Di{4-[difluoro(phosphono)methyl]benzyl}malonic acid, dibenzyl ester → 2,2-Di{4-[Difluoro(Phosphono)Methyl]Benzyl}Malonic Acid

Participants

Reaction Steps

A mixture of the product of Example 2 (0.2 g), PdCl2 and a few drops of HCO2H in 20 mL of MeOH was shaken under 50 psi of H2 for 24 h. The reaction mixture was filtered through celite and the filtrate was concentrated. The residue was lyopholized to give 0.1 g of the title compound.

Provenance & Evidence