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HRID56650

反应详情

EQUATION

反应方程式

HRID 56650 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)OC(=O)c1ccc(N)cc1
HCID233272

Benzoic acid, 4-amino-, 1,1-dimethylethyl ester

C11H15NO2

结构：CC(C(=O)O)n1ccc(-c2cc(Cl)ccc2C(F)(F)F)cc1=O
HCID117622750

未命名化合物

PRODUCTS

生成物

1
结构：CC(C(=O)Nc1ccc(C(=O)OC(C)(C)C)cc1)n1ccc(-c2cc(Cl)ccc2C(F)(F)F)cc1=O
HCID117622747

未命名化合物

PROCEDURE

实验过程

130 mg (purity 93%, 0.35 mmol) of 2-{4-[5-chloro-2-(trifluoromethyl)phenyl]-2-oxopyridin-1(2H)-yl}propanoic acid (racemate) and 1.2 eq. of tert-butyl 4-aminobenzoate were reacted according to General Method 5A. The crude product was purified by preparative HPLC (Reprosil C18, water/methanol gradient). Yield: 104 mg (56% of theory)

WORKUP

后处理

  1. customThe crude product was purified by preparative HPLC (Reprosil C18, water/methanol gradient)