Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Bromo-2-hydroxypyridine → tert-Butyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)butanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Bromo-2-hydroxypyridine | HCID 817115 | — |
| 반응물 | tert-Butyl 2-bromobutanoate | HCID 13124118 | — |
| 생성물 | tert-Butyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)butanoate | HCID 117622861 | — |
반응 단계
348 mg (2.0 mmol) of 4-bromopyridin-2(1H)-one and 1.2 eq. of tert-butyl 2-bromobutanoate (racemate) were reacted according to General Method 4B at 120° C. After aqueous work-up, the desired product was reacted further as crude product. Yield: 608 mg (purity 82%, 79% of theory)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09434690B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-14b2ea9e819e44e5aba150649ad2e6ec |
| 출처 메모 | uspto-grants-2016_09 |