HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Phenylacetophenone → 1,2,3-triphenylpropan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Phenylacetophenone | HCID 9948 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Benzyl Bromide | HCID 7498 | — |
| Product | 1,2,3-triphenylpropan-1-one | HCID 233432 | — |
Reaction Steps
To deoxybenzoin (0.20 g, 1.02 mmol) in DMF (5 mL) were added at 0° C. NaH in oil (0.050 g, 1.22 mmol) and benzyl bromide (183 μL). After 1 h at room temperature, the reaction mixture was partitioned between NH4OAc and ether. After usual work up procedure the title compound was purified by flash chromatography (0.95 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06174874B1 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-3ad1d3486b6648579074d670d1e39c51 |
| Source note | uspto-grants-2001_01 |